Home/Supplement Brand Marketing/Supplement Facts Panel
[01] Label guide, 21 CFR 101.36

The Supplement Facts Panel: How to Read It and Build It Right

Every number on your Supplement Facts panel follows a federal rule, and on Amazon every number in your listing has to match it. Here is the panel line by line, with a worked example you can check your own label against.

Last reviewed October 27, 2026Sources checked October 2026By Ian Smith

Short answer

A Supplement Facts panel is the nutrition label FDA requires on dietary supplements under 21 CFR 101.36. It lists the serving size, servings per container, each dietary ingredient's amount per serving, and a percent Daily Value for nutrients that have one. Ingredients with no Daily Value get a symbol, often a dagger, pointing to the footnote "Daily Value not established."

8 pt

Minimum type size for most text inside the panel, with 6 pt allowed for column headings and footnotes

21 CFR 101.36(e)

420 mg

Daily Value for magnesium for adults and children 4 and older; divide the magnesium amount by it to get %DV

21 CFR 101.9(c)(8)(iv)

100%

Minimum share of the labeled amount an added vitamin or mineral must test at in FDA compliance testing

21 CFR 101.9(g)(4)(i)

12

Consumer packages FDA combines into one test sample, or 10 percent of the lot if that is smaller

21 CFR 101.36(f)(1)

[02] The basics

What a Supplement Facts Panel Is and Why It Runs Your Listing

Disclosure: Disclosure: Evolve Media Agency designs supplement labels, listing images and A+ content, and sells monthly brand management plans to supplement brands. This guide explains the published rules so you can check your own panel. We are not lawyers, and nothing here is legal advice. Before you print a new label, talk to a regulatory attorney.

The Supplement Facts panel is the boxed nutrition label on a supplement bottle. FDA requires it on every dietary supplement offered for sale, apart from narrow exemptions, under 21 CFR 101.36. CFR is the Code of Federal Regulations, the official book of federal rules. Section 101.36 sets what goes in the panel, in what order, in what units and how it looks.

This page goes deeper on the panel than our supplement label requirements guide, which covers the whole label. Use that one for the front of the bottle and this one for the panel.

The panel matters even more on Amazon. NutraIngredients reported that Amazon rolled out an updated U.S. supplement policy on March 31, 2026, under which claims in the title, bullets, images or description must match the panel exactly, with automated scanning for mismatches (NutraIngredients, March 2026). The panel is now the document your listing is written from.

Supplement Facts (supplements)Nutrition Facts (conventional foods)
Can list ingredients with no Daily Value, such as botanicals, by weightLists only nutrients FDA has defined
Can name the source in parentheses, such as Magnesium (as magnesium glycinate)Source ingredients stay in the ingredient list
Botanicals must name the plant part used, such as root or leafPlant parts are not listed in the panel
Nutrients present at zero are not listedRequired nutrients are listed even at zero
Proprietary blends can show one total weightNo proprietary blend format
The differences above come from FDA's Dietary Supplement Labeling Guide, Chapter IV. The guide dates from 2005, so where it and the current eCFR text disagree, this page follows the eCFR.
[03] Top to bottom

How to Read the Panel: Serving Size, Amounts and %DV

Read the panel in the order FDA builds it. Each part answers one question, and each part has a rule behind it that a buyer, a lab or an Amazon reviewer can check.

Serving Size

The heading must say "Serving Size" and the unit fits the form, such as tablets, capsules, packets or scoops (101.36(b)(1)(i)). The serving is the most your label tells someone to take at one time, per 21 CFR 101.12(b). If the directions say 1 to 3 tablets, the serving is 3 tablets.

Servings Per Container

Goes directly under Serving Size, unless the net quantity statement on the front already says it (101.36(b)(1)(ii)). A 60-capsule bottle with a 2-capsule serving has 30 servings.

Amount Per Serving

The heading over the amounts. You may use wording that matches the serving, such as "Amount Per 2 Capsules" (101.36(b)(2)(i)(A)). Each amount is the weight of the nutrient, not its source: the calcium, not the calcium carbonate (101.36(b)(2)(ii)).

% Daily Value

For each nutrient that has a Daily Value, divide the unrounded amount by the Daily Value and multiply by 100, then round to the nearest whole percent (101.36(b)(2)(iii)(B) and (C)). The heading may also read % DV, Percent Daily Value or Percent DV.

The heavy bar and the dagger

Below a heavy bar come the other dietary ingredients that have no Daily Value, such as most herbs, amino acids and creatine. Each gets a symbol in the %DV column that points to a footnote reading "Daily Value not established" (101.36(b)(3)(iv)). The rule says a symbol, for example an asterisk. FDA's own sample labels use a dagger for this footnote when the asterisk is already in use for the calorie footnote.

Footnotes

If the panel declares a %DV for total fat, saturated fat, total carbohydrate, dietary fiber, protein or added sugars, you also need the footnote "Percent Daily Values are based on a 2,000 calorie diet" (101.36(b)(2)(iii)(D)). Gummies and powders can trigger it, because they often carry sugar or carbohydrate. Most capsules do not.

Which nutrients must appear? Under 101.36(b)(2)(i), calories, fats, cholesterol, sodium, carbohydrate, fiber, sugars, protein, vitamin D, calcium, iron and potassium are listed whenever present above the amount that rounds to zero. FDA's labeling guide adds that other vitamins and minerals are declared when added for supplementation or when the label makes a claim about them. Vitamins and minerals below 2 percent of their Daily Value are left off. FDA's Daily Value page lists every Daily Value in one table.

Vitamins and minerals run in a fixed order set by 101.36(b)(2)(i)(B), starting with vitamin A, vitamin C, vitamin D, vitamin E and vitamin K, then the B vitamins, then minerals from calcium and iron through potassium and fluoride. Vitamin D must be declared in micrograms; IU is optional and goes in parentheses after the microgram amount (101.36(b)(2)(ii)(B)).

[04] One panel, explained

A Worked Example Panel, Line by Line

Here is a panel for a made-up capsule product we will call a magnesium and ashwagandha formula. The directions say "Take 2 capsules daily," and the bottle holds 60 capsules. Read it top to bottom as it would print inside the hairline box, then check the math notes underneath.

Panel lineWhat prints, and why
TitleSupplement Facts, bold, larger than anything else in the panel, full width of the box (101.36(e)(1))
Serving Size2 Capsules. The directions say 2, so the serving is 2.
Servings Per Container30. Sixty capsules divided by 2. A heavy bar goes under this line (101.36(e)(6)(i)).
Column headingsAmount Per 2 Capsules on the left, % Daily Value on the right, on the same line, with a light bar beneath (101.36(e)(7))
Vitamin D (as cholecalciferol)20 mcg (800 IU), 100%. The Daily Value for vitamin D is 20 mcg, so 20 divided by 20 is 100 percent.
Magnesium (as magnesium glycinate)200 mg, 48%. 200 mg is elemental magnesium, not the weight of the glycinate. 200 divided by the 420 mg Daily Value is 47.6 percent, which rounds to 48.
Heavy barCloses the section of nutrients that have Daily Values (101.36(e)(6)(ii))
Ashwagandha root extract300 mg, †. The plant part (root) is required, and the weight is the dried extract (101.36(b)(3)(ii)(C)).
L-Theanine100 mg, †. An amino acid with no Daily Value.
Heavy bar and footnote† Daily Value not established. Placed inside the box, below the last heavy bar (101.36(b)(3)(iv)).
Below the boxOther ingredients: hypromellose (capsule), rice flour, magnesium stearate. Sources already named in the panel do not repeat here (101.36(d)).

Notice what is not in the panel. There is no calorie line, because we assume two capsules carry under 5 calories, which 101.9(c)(1) lets you express as zero, and a supplement panel does not list zeros. There is no 2,000 calorie footnote, because no %DV is declared for fat, carbohydrate, fiber, protein or added sugars. Switch to a gummy and both usually come back, along with total sugars and added sugars.

Daily Values come from the table in 21 CFR 101.9(c)(8)(iv). Common ones for adults and children 4 and older: vitamin C 90 mg, vitamin D 20 mcg, calcium 1,300 mg, iron 18 mg, magnesium 420 mg, zinc 11 mg. Products labeled for young children or for pregnant or lactating women use that group's values, and the %DV heading must name the group (101.36(b)(2)(iii)(E)).

This example is for teaching only. It is not a formula recommendation and makes no claim about what the ingredients do. If you add a claim such as "supports a calm mood," the label also needs the FDA disclaimer, covered in our structure/function claims guide.
Want a second set of eyes on this? Book a free 30-minute call, email Ian at [email protected], or call or text 719-257-3557. Send us your draft panel or formula sheet and we will check it against your listing before you print.
[05] The tricky parts

Proprietary Blends and Source Ingredients

Two features exist only on Supplement Facts panels, and both are common places for a listing to drift away from the label.

Proprietary blends

A blend is named with the term "Proprietary Blend" or another descriptive or fanciful name, with one total weight on the same line. That total covers only the other dietary ingredients in it. Those ingredients are indented underneath in descending order by weight, and the blend carries the Daily Value symbol (101.36(c)(2) and (c)(3)). FDA's sample shows a 0.7 g blend of German chamomile (flower) and hyssop (leaf).

Vitamins and minerals cannot hide in a blend

Any nutrient with a Daily Value inside a blend still gets its own amount and %DV, declared the normal way (101.36(c)(1)).

Blends and your Amazon listing

If the panel shows only a blend total, the listing cannot state an amount for one ingredient inside it. Amazon's policy requires ingredient weights in the listing to match the panel. Our Amazon supplement policy guide covers that rule.

Source ingredients

You may name the source in parentheses after the nutrient, preceded by "as" or "from," for example Calcium (as calcium carbonate). If two or more sources supply one nutrient, list all of them in descending order by weight (101.36(d)(2)). A source named in the panel does not need to repeat in the ingredient list (101.36(d)).

[06] For your designer

Formatting Rules Your Designer Has to Follow

Most panel errors on new labels are layout errors, not math errors. Hand this table to whoever builds the artwork.

Format ruleRequirement and citation
BoxAll panel information inside a box drawn with hairlines (101.36(e)(2))
Type styleOne easy-to-read type style, all black or one color, on a white or neutral contrasting background when practical (101.36(e)(3))
Minimum type size8 point for most text; 6 point for column headings and footnotes (101.36(e)(4))
Small packagesUnder 12 square inches of label space: 4.5 point minimum. From 12 to 40 square inches: 6 point, with 4.5 point allowed in some cases (101.36(i)(2))
Bars and rulesA hairline between each ingredient; heavy bars under servings per container, under the last Daily Value nutrient and under the last other dietary ingredient; a light bar under the column headings (101.36(e)(5) to (e)(7))
PlacementOn the information panel or principal display panel per 21 CFR 101.2, with the ingredient list directly below the panel, or to its right if there is no room below (101.36(d) and (g))
[07] Step by step

How to Build a Supplement Facts Panel in 8 Steps

1

Get the final formula in writing

Ask your manufacturer for each dietary ingredient, its source form, and its amount per unit. For minerals, ask for the elemental amount, since that is the number that prints. Our guide to vetting a supplement manufacturer covers what else to request.

2

Set the directions, then the serving size

Write the directions first. The serving size is the most the directions tell someone to take at one time.

3

Sort ingredients into two groups

Group one: nutrients with a Daily Value, in the order 101.36 sets. Group two: everything else, such as botanicals and amino acids. Decide now whether any group-two ingredients will sit in a proprietary blend.

4

Calculate each %DV

Divide the unrounded amount by the Daily Value in 21 CFR 101.9(c)(8)(iv), multiply by 100 and round to the nearest whole percent. Drop any vitamin or mineral below 2 percent of its Daily Value. Check every result twice.

5

Add symbols and footnotes

Put a symbol next to each group-two ingredient and blend, with the "Daily Value not established" footnote. Add the 2,000 calorie footnote only if a %DV appears for fat, carbohydrate, fiber, protein or added sugars.

6

Lay it out to the format rules

Build the box, bars and hairlines, then check type sizes against the label area you actually have. Measure on a printed proof, not a screen.

7

Write the ingredient list below it

List every non-dietary ingredient by descending weight, including capsule shell, fillers and flavors, headed "Other ingredients" if sources are already named inside the panel.

8

Write the listing from the panel

Copy names, amounts and serving size from the panel into your title, bullets and images word for word, then photograph the printed label for Amazon.

Plan for testing while you build. Under 101.36(f)(1), FDA judges compliance on a composite sample using the Class I and Class II rules in 101.9(g): added nutrients must test at 100 percent or more of the label, naturally occurring ones at 80 percent or more, and those rules also apply to botanicals and other dietary ingredients. Reasonable overages are allowed within good manufacturing practice. See Amazon supplement testing requirements for how Amazon's labs use the same numbers. Formats that lose potency over time need extra care; our creatine gummies page shows why.
[08] What goes wrong

Common Supplement Facts Mistakes and How to Catch Them

Serving size smaller than the directions

In a January 2026 warning letter, FDA said a capsule product was misbranded because the directions said 1 to 2 capsules once daily while the serving size listed 1 capsule. FDA said it should have been 2 (FDA warning letter, January 2026).

Source weight instead of nutrient weight

A panel that prints 1,000 mg, the weight of the magnesium glycinate, when the elemental magnesium is far less. The rule wants the nutrient's weight (101.36(b)(2)(ii)).

Missing plant part

"Ashwagandha extract" alone is incomplete. FDA's labeling guide says the panel must name the part of the plant, such as root.

A listing that says more than the panel

A title that turns a 300 mg extract into a large raw-herb equivalent, or a bullet that gives an amount for one ingredient inside a blend. Amazon's policy treats these as mismatches.

A quick self-check: cover the panel, read only your Amazon title and bullets, and write down every ingredient amount they promise. Then uncover the panel. Every number you wrote should be printed there, in the same unit, for the same serving.

[09] Honest guidance

When to Get Help and When to Do It Yourself

Do it yourself if your formula is simple, your manufacturer hands you a draft panel, and you have time to check it against this page. Your job is to check the math, the serving size and the listing match.

Talk to a regulatory attorney if you use an ingredient that may be a new dietary ingredient, sell a product for children or pregnant women, or plan to sell outside the U.S.

Get design and listing help if the panel is right but the label does not fit the bottle, or your listing and images do not match the panel. That is where Evolve fits. Label and packaging design is quoted per project or done inside brand management hours. Listing images and Premium A+ run $295, $495 or $595 through graphic design, and a listing rewrite built from your panel is $495 through listing optimization.

Monthly plans run from Brand Support at 5 hours for $750 to Brand Manager at 10 hours for $1,250, Brand Manager Plus at 20 hours for $2,000 and Full Brand Management at 40 hours for $3,600, paid upfront and month to month. See brand management for supplement brands. To have us check a draft panel against your listing, email Ian at [email protected] or call or text 719-257-3557.

Evolve does not certify labels, give legal advice or run lab tests. Your manufacturer supplies the formula and documents, a lab confirms the numbers, and your attorney signs off on anything novel. For the bigger picture, see our supplement brand marketing page and our plain answer to whether FDA approves supplements.
[11] Who Wrote This

About the Author

Ian Smith, founder of Evolve Media Agency

Ian Smith

Founder, Evolve Media Agency

Ian has run Evolve Media Agency since 2017 and has sold on Amazon since 2015. He and Megan run brand management, launches, PPC and in-house photo and video for Amazon, Shopify and TikTok Shop brands, including supplement brands, from Colorado. Questions about this page go straight to him at [email protected].

  Watch on YouTube →

[12] FAQ

Common Questions

What is the difference between Supplement Facts and Nutrition Facts?
Supplements use a Supplement Facts panel under 21 CFR 101.36; conventional foods use Nutrition Facts under 21 CFR 101.9. The supplement panel can list ingredients with no Daily Value, such as herbs, can name sources in parentheses, must name the plant part for botanicals, can show proprietary blends by total weight, and leaves out nutrients present at zero.
What does the dagger symbol mean on a supplement label?
The dagger usually points to the footnote "Daily Value not established." It marks ingredients such as herbs, amino acids or creatine that FDA has not set a Daily Value for. The rule only requires a symbol, for example an asterisk, but FDA's own sample labels use a dagger for this footnote when the asterisk is already used for the 2,000 calorie footnote.
How is serving size set on a supplement?
Serving size is the most your label tells someone to take at one time, under 21 CFR 101.12(b). If the directions say take 1 to 3 tablets with breakfast, the serving size is 3 tablets. In January 2026, FDA cited a company whose directions said 1 to 2 capsules while its panel listed a 1 capsule serving.
How do you calculate %DV on a Supplement Facts panel?
Divide the unrounded amount per serving by the Daily Value in 21 CFR 101.9(c)(8)(iv), multiply by 100 and round to the nearest whole percent. For example, 200 mg of magnesium divided by the 420 mg Daily Value is 47.6 percent, which prints as 48%. Vitamins and minerals below 2 percent of the Daily Value are not listed.
Is a proprietary blend legal on a supplement label?
Yes. Under 21 CFR 101.36(c), a blend can show one total weight for its other dietary ingredients, listed underneath in descending order by weight. Vitamins and minerals in the blend still need individual amounts. On Amazon, your listing cannot state an amount for an ingredient inside a blend that the panel does not show.
Does my Amazon listing have to match the Supplement Facts panel?
Yes. As of October 2026, Amazon's dietary supplement policy expects ingredient names, amounts and serving sizes in the listing to match the panel, and asks for images of the full label. Trade press reported automated mismatch checks from March 31, 2026. Confirm the current wording in Seller Central.
Can Evolve build my Supplement Facts panel and listing?
Yes. Evolve designs supplement labels, quoted per project or done inside brand management hours, and builds listing images, A+ content and copy that match the panel. We check against the published rules but are not regulatory counsel, so novel ingredients should also go to an attorney. Email [email protected] or call or text 719-257-3557.

Free · 30 minutes · No pitch deck

Want a Second Set of Eyes on Your Panel?

Book a free 30-minute call and bring your draft panel, formula sheet or ASIN. We will check the panel against your listing and tell you what, if anything, needs to change.

Rather email? Write Ian at [email protected]. Call or text 719-257-3557. Watch our YouTube channel, grab the free Ecom Profit Box guides, or join the newsletter.

Free 30-minute call

Want Ian to Look at Your Brand?

Tell us what you sell and where you are stuck. Ian replies within one business day, and you get an email right away with a link to book a free 30-minute call.

  • Brand management, PPC, listings, launches and content
  • Amazon, Shopify and TikTok Shop brands
  • A real reply from Ian, not a sales bot

Rather talk now? Call or text 719-257-3557 or pick a time on Calendly.

Your information stays with us. We never share it.